These highlights do not include all the information needed to use temodar safely and effectively. Temodar temozolomide capsules should not be opened or chewed. Toposar is contraindicated in patients who have demonstrated a previous hypersensitivity to it. Incivek telaprevir film coated tablets, for oral use initial u. Highlights of prescribing information valcytefor oral. Highlights of prescribing information these highlights do not include all the information needed to use advate safely and effectively.
Highlights of prescribing information nss are frequent nss. Pdf telaprevir for previously untreated chronic hepatitis c. Do not crush, chew or break tablets before swallowing 2. It was approved in europe in september 2011 for treatment of adults with genotype 1 chronic hepatitis c in combination with pegylated interferon and ribavirin. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Anemia mechanism of anemia thought to be result of bone marrow suppressive effect associated with telaprevir, not rbc hemolysis patients treated with telaprevir had a higher frequency of anemia, hemoglobin level incivek telaprevir, in combination with peginterferon alfa and ribavirin, is indicated for the treatment of genotype 1 chronic hepatitis c in adult patients with compensated liver disease, including cirrhosis, who are treatmentnaive or who have previously been treated with interferonbased treatment, including. Jan 25, 2019 initiate actos at 15 mg or 30 mg once daily. Victrelis must be administered in combination with peginterferon alfa and ribavirin.
If capsules are accidentally opened or damaged, precautions should be taken to avoid inhalation or contact with the skin or mucous membranes see how suppliedstorage and handling 16. Do not administer with highfat meals, because of increased exposure 2. Center the spike within the circle on the stopper top. Highlights of prescribing information 3 prs 16 weeks 16. Incivek telaprevir, in combination with peginterferon alfa and ribavirin, is indicated for the treatment of genotype 1 chronic hepatitis c in adult patients with compensated liver disease, including cirrhosis, who are treatmentnaive or who have previously been treated with interferonbased treatment, including. Valcytevalganciclovirtablets, valcytevalganciclovir hydrochloride fororal solution initial u. However, as stated in the telaprevir package insert treatment. This emedtv segment further explores telaprevirs mechanism of action and provides a link to more detailed information on this prescription drug. The information in this table was obtained from package inserts for boceprevir and telaprevir february 2012. Telaprevir for previously untreated chronic hepatitis c virus infection article pdf available in new england journal of medicine 36425. Pharmacist information sheet important dispensing information for every patient, temodar must be dispensed in a separate vial or in its. Anemia mechanism of anemia thought to be result of bone marrow suppressive effect associated with telaprevir, not rbc hemolysis patients treated with telaprevir had a higher frequency of anemia, hemoglobin level inc. The pdf file should be the first option within the insert dialog window. Highlights of prescribing information these highlights do not include all the information needed to use valcyte safely and effectively.
Begin at a dose of 1 mg once daily and adjust in increments of no more than 1 mgweek 2. Warnings patients being treated with toposar must be frequently observed for myelosuppression both during and after therapy. After one week, increase the dose to the recommended. Dec 29, 2011 however, as stated in the telaprevir package insert treatment. Doselimiting bone marrow suppression is the most significant toxicity associated with etoposide therapy. The studies identified assessed boceprevir and telaprevir in genotype1 hepatitis c patients. When possible, interrupt therapy with brilinta for fivedays prior to surgery that has a major risk of bleeding. Highlights of prescribing information for intravenous.
Effects of boceprevir and telaprevir on the pharmacokinetics. Excel for office 365 word for office 365 outlook for office 365 powerpoint for office 365 publisher for office 365 visio plan 2 word for the web visio professional 2019 visio standard 2019 visio professional 2016 visio standard 2016 visio professional 20 visio. How to insert a pdf into powerpoint online tech tips. Telaprevir should be used with caution with warfarin because telaprevir can increase or decrease warfarin coumadin breakdown, increasing or decreasing the effect of warfarin. Faslodex fulvestrant injection 500 mg for health care. When possible, interrupt therapy with brilinta for fivedays prior to. For the treatment of hepatitis c with telaprevir, the standard dose is 1125 mg taken two times daily. Telaprevir is used along with two other medications ribavirin copegus, rebetol and peginterferon alfa pegasys to treat chronic hepatitis c an ongoing viral infection that damages the liver in people who have not yet been treated for this condition or whose condition could not successfully be treated with ribavirin and peginterferon alfa alone. Telaprevir crosses into the breast milk and it is recommend for women to use two forms of birth control while on this medication. Full prescribing information 1 indications and usage ingrezza is indicated for the treatment of adults with tardive dyskinesia see clinical studies 14. In both treatmentnaive and treatmentexperienced patients, sustained virological response rates were achieved more often with boceprevir or telaprevir in combination with pegylated interferon and ribavirin compared with pegylated interferon and ribavirin alone. Highlights of prescribing information these highlights. This medicine comes with an extra patient fact sheet called a medication guide. The apparent volume of distribution at steady state ranged from 43 to 90 l.
Open the ppt and go on the slide that you want to insert a pdf into. Page 1 of 36 highlights of prescribing information these highlights do not include all the information needed to use perjeta safely and effectively. Highlights of prescribing information coadministration of. Ribavirin fda prescribing information, side effects and uses. By blocking the activity of certain enzymes, telaprevir can prevent the hepatitis c virus from multiplying.
Follow the package insert for the management of rash. This emedtv page takes a closer look at dosing guidelines, with details on why this medication is not used alone and helpful tips on taking telaprevir. These highlights do not include all the information needed to use apokyn safely and effectively. The aim was to evaluate the effect of boceprevir and telaprevir on dolutegravir pharmacokinetics pk. Cutaneous eruption due to telaprevir fulltext case reports in.
When using an intravenous infusion pump, administer integrilin undiluted directly from the 100ml vial. Thus, there is a significant pharmacokinetic interaction between telaprevir and ribavirin that results in very high. Apokyn apomorphine hydrochloride injection, for subcutaneous use initial u. Consult a pharmacist or the package insert for information about each drugs safety during pregnancy and breastfeeding. Learn more about faslodex fulvestrant injection 500 mg, a treatment option for hr positive, her2 negative advanced breast cancer in postmenopausal women not previously treated with endocrine therapy. Mavyret is indicated for the treatment of adult and pediatric patients 12 years and older or weighing at least 45 kg with hcv genotype 1 infection, who previously have been treated with a regimen containing an hcv ns5a inhibitor or an ns34a protease inhibitor, but not both. Insert pdf file content into a powerpoint presentation powerpoint. The dose of victrelis is 800 mg four 200mg capsules three times daily every 79 hours with food a meal or light snack see table 1. Used to treat pulmonary hypertension at high doses.
Highlights of prescribing information hypersensitivity to. Highlights of prescribing information incivek tm initial u. Limit initial dose to 15 mg once daily in patients with nyha class i or ii heart failure. Highlights of prescribing information these highlights do not include all the information needed to use incivek safely and effectively. Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir. Open powerpoint and create a new presentation or open an existing ppt file. If there is inadequate glycemic control, the dose can be increased in 15 mg increments up to a maximum of 45 mg once daily. Telaprevir mechanism of action hepatitis home page. Package insert and patient information 10 ml of sterile water for injection using baxject ii pdf 187kb package insert and patient information 5 ml of sterile water for injection using. Refer to the peginterferon alfa and ribavirin package inserts for instructions on dosing. Advate antihemophilic factor recombinant, plasmaalbuminfree method for intravenous use, lyophilized powder for reconstitution initial u.
Severe rash like stevenjohnson syndrome or drug rash with eosinophilia and systemic symptoms are very rare. Dispense enclosed patient package insert to each patient. Consult a pharmacist or the package insert for information about each. Ribavirin for inhalation has a separate package insert, which should be consulted if ribavirin inhalation therapy is being considered. Review of boceprevir and telaprevir for the treatment of. They should be swallowed whole with a glass of water. Consult the full prescribing information prior to use for potential drug interactions. Rna at weeks 4 and 12 of telaprevir combination treatment may benefit from an additional 36 weeks of peg. This emedtv segment further explores telaprevir s mechanism of action and provides a link to more detailed information on this prescription drug. Drug class contraindicated with boc1 contraindicated with tvr2 alpha 1. Unless otherwise specified, the information in the following summaries applies to adults, not children. Open your powerpoint presentation on the page you want to insert the pdf within. Current standards and new paradigms is the property of its rightful owner. Ribavirin should be given in combination with peginterferon alfa2a.
Telaprevir can slow the breakdown of these medications and increase their levels in the body, leading to increased side effects and toxicity. Click the image and it will be inserted into the slide. Youve just received a pdf from a client or coworker, and you need to add the content to your powerpoint presentation. To insert a pdf into powerpoint without losing quality, follow the steps below. Telaprevir is only indicated for use against hepatitis c genotype 1 viral infections and has not been proven to have an effect on or being safe when used for other genotypes of the virus. Telaprevir should be used with caution with warfarin because telaprevir can increase or decrease warfarin coumadin breakdown, increasing or. Telaprevir brand name incivo is a new medication used to treat hepatitis c. If you have any questions about telaprevir, please talk with the doctor, pharmacist, or other health care provider. Apr 26, 2012 the information in this table was obtained from package inserts for boceprevir and telaprevir february 2012. Administer integrilinby volume according to patient weightsee table1.
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